APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that co...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Cooper, Anneli, Ilboudo, Hamidou, Alibu, V Pius, Ravel, Sophie, Enyaru, John, Weir, William, Noyes, Harry, Capewell, Paul, Camara, Mamadou, Milet, Jacqueline, Jamonneau, Vincent, Camara, Oumou, Matovu, Enock, Bucheton, Bruno, MacLeod, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Genomics and Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495568/
https://ncbi.nlm.nih.gov/pubmed/28537557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25461
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