APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that co...

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Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Cooper, Anneli, Ilboudo, Hamidou, Alibu, V Pius, Ravel, Sophie, Enyaru, John, Weir, William, Noyes, Harry, Capewell, Paul, Camara, Mamadou, Milet, Jacqueline, Jamonneau, Vincent, Camara, Oumou, Matovu, Enock, Bucheton, Bruno, MacLeod, Annette
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Genomics and Evolutionary Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495568/
https://ncbi.nlm.nih.gov/pubmed/28537557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25461
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