Optogenetic control of mitochondrial metabolism and Ca(2+) signaling by mitochondria-targeted opsins

Key mitochondrial functions such as ATP production, Ca(2+) uptake and release, and substrate accumulation depend on the proton electrochemical gradient (ΔμH(+)) across the inner membrane. Although several drugs can modulate ΔμH(+), their effects are hardly reversible, and lack cellular specificity a...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Tkatch, Tatiana, Greotti, Elisa, Baranauskas, Gytis, Pendin, Diana, Roy, Soumitra, Nita, Luliaoana I., Wettmarshausen, Jennifer, Prigge, Matthias, Yizhar, Ofer, Shirihai, Orian S., Fishman, Daniel, Hershfinkel, Michal, Fleidervish, Ilya A., Perocchi, Fabiana, Pozzan, Tullio, Sekler, Israel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495261/
https://ncbi.nlm.nih.gov/pubmed/28611221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703623114
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