Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity

The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14) consists of two CRISPR loci and six CRISPR-associated (cas) genes. Type I-F systems rely on a CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreign DNA and recruit a trans-acting nuclease (i.e., Cas2/3...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rollins, MaryClare F., Chowdhury, Saikat, Carter, Joshua, Golden, Sarah M., Wilkinson, Royce A., Bondy-Denomy, Joseph, Lander, Gabriel C., Wiedenheft, Blake
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495223/
https://ncbi.nlm.nih.gov/pubmed/28438998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616395114
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