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A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination
OBJECTIVE: Our goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and determine its relevance to human white matter disease. METHODS: Based on previous localization of the taiep mutation to rat chromosome 9, we tested if the mutation resided within the Tubb4a...
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| 出版年: | Ann Neurol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495199/ https://ncbi.nlm.nih.gov/pubmed/28393430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24930 |
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