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Biosynthesis of the Pharmaceutically Important Fungal Ergot Alkaloid Dihydrolysergic Acid Requires a Specialized Allele of cloA

Ergot alkaloids are specialized fungal metabolites that are important as the bases of several pharmaceuticals. Many ergot alkaloids are derivatives of lysergic acid (LA) and have vasoconstrictive activity, whereas several dihydrolysergic acid (DHLA) derivatives are vasorelaxant. The pathway to LA is...

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Bibliografiset tiedot
Julkaisussa:Appl Environ Microbiol
Päätekijät: Arnold, Stephanie L., Panaccione, Daniel G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494617/
https://ncbi.nlm.nih.gov/pubmed/28476772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00805-17
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