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Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA
Several genomic disorders are caused by an excessive number of DNA triplet repeats. We developed a DNA-templated reaction in which product formation occurs only when the number of repeats exceeds a threshold indicative for the outbreak of Chorea Huntington. The combined use of native chemical PNA li...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5494559/ https://ncbi.nlm.nih.gov/pubmed/28706635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01974a |
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