Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non‐conventional repeat translation results in five dipeptide repeat proteins (DPRs), but their clinical utility, overall significance, and temporal course in the pathogenes...

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Publicat a:EMBO Mol Med
Autors principals: Lehmer, Carina, Oeckl, Patrick, Weishaupt, Jochen H, Volk, Alexander E, Diehl‐Schmid, Janine, Schroeter, Matthias L, Lauer, Martin, Kornhuber, Johannes, Levin, Johannes, Fassbender, Klaus, Landwehrmeyer, Bernhard, Schludi, Martin H, Arzberger, Thomas, Kremmer, Elisabeth, Flatley, Andrew, Feederle, Regina, Steinacker, Petra, Weydt, Patrick, Ludolph, Albert C, Edbauer, Dieter, Otto, Markus, Danek, Adrian, Feneberg, Emily, Anderl‐Straub, Sarah, von Arnim, Christine, Jahn, Holger, Schneider, Anja, Maler, Manuel, Polyakova, Maryna, Riedl, Lina, Wiltfang, Jens, Ziegler, Georg
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494528/
https://ncbi.nlm.nih.gov/pubmed/28408402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607486
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