Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice

Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non‐syndromic hydrocephalus. To investigate functions of the tight junction‐associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional inactivatio...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Feldner, Anja, Adam, M Gordian, Tetzlaff, Fabian, Moll, Iris, Komljenovic, Dorde, Sahm, Felix, Bäuerle, Tobias, Ishikawa, Hiroshi, Schroten, Horst, Korff, Thomas, Hofmann, Ilse, Wolburg, Hartwig, von Deimling, Andreas, Fischer, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494508/
https://ncbi.nlm.nih.gov/pubmed/28500065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606430
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