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Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study

BACKGROUND: Recent studies have suggested that the tumor necrosis factor-α (TNF-α) pathway is a potential target for the management of osteoarthritis (OA). Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is essential in several cytokine-mediated cascades, including the TNF-α, interleuki...

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Detalhes bibliográficos
Publicado no:BMC Musculoskelet Disord
Main Authors: Uchida, Kentaro, Takano, Shotaro, Matsumoto, Toshihide, Nagura, Naoshige, Inoue, Gen, Itakura, Makoto, Miyagi, Masayuki, Aikawa, Jun, Iwase, Dai, Minatani, Atsushi, Fujimaki, Hisako, Takaso, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493881/
https://ncbi.nlm.nih.gov/pubmed/28668088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-017-1648-4
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