Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress

The Yeast Knockout (YKO) collection has provided a wealth of functional annotations from genome-wide screens. An unintended consequence is that 76% of gene annotations derive from one genotype. The nutritional auxotrophies in the YKO, in particular, have phenotypic consequences. To address this issu...

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Vydáno v:Open Biol
Hlavní autoři: Acton, Erica, Lee, Amy Huei-Yi, Zhao, Pei Jun, Flibotte, Stephane, Neira, Mauricio, Sinha, Sunita, Chiang, Jennifer, Flaherty, Patrick, Nislow, Corey, Giaever, Guri
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493772/
https://ncbi.nlm.nih.gov/pubmed/28592509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160330
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