High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice

SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2. To investigate the molecular mechanisms of neurodegeneration in SLC19A3 defi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Suzuki, Kaoru, Yamada, Kenichiro, Fukuhara, Yayoi, Tsuji, Ai, Shibata, Katsumi, Wakamatsu, Nobuaki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493381/
https://ncbi.nlm.nih.gov/pubmed/28665968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180279
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