HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6

All-trans retinoic acid (ATRA) induces complete remission in almost all patients with acute promyelocytic leukemia (APL) via its ability to induce the in vivo differentiation of APL blasts. However, prolonged ATRA treatment can result in drug resistance. In previous studies, we generated a multi-dru...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Shuangshuang, Jin, Xianqing, Wu, Huan, Wang, Yi, Li, Xiaoqing, Guo, Yuxia, Liang, Shaoyan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493346/
https://ncbi.nlm.nih.gov/pubmed/28665981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180142
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