Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence

Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti-viral innate immune responses affect parasitic i...

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Pubblicato in:Cell Host Microbe
Autori principali: Eren, Remzi Onur, Reverte, Marta, Rossi, Matteo, Hartley, Mary-Anne, Castiglioni, Patrik, Prevel, Florence, Martin, Ricardo, Desponds, Chantal, Lye, Lon-Fye, Drexler, Stefan K., Reith, Walter, Beverley, Stephen M., Ronet, Catherine, Fasel, Nicolas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493041/
https://ncbi.nlm.nih.gov/pubmed/27593513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.08.001
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