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Structural basis of MeCP2 distribution on non-CpG methylated and hydroxymethylated DNA

The Rett syndrome-associated methyl-CpG binding protein 2 (MeCP2) selectively binds methylated DNA to regulate transcription during the development of mature neurons. Like other members of the methyl-CpG binding domain (MBD) family, MeCP2 functions through the recognition of symmetrical 5-methylcyto...

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Foilsithe in:J Mol Biol
Main Authors: Sperlazza, M. Jeannette, Bilinovich, Stephanie M., Sinanan, Leander M., Javier, Fatima R., Williams, David C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492995/
https://ncbi.nlm.nih.gov/pubmed/28450074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.04.009
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