Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer

The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated. In the present study, a single-i...

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Vydáno v:Mol Clin Oncol
Hlavní autoři: Kimura, Madoka, Imamura, Fumio, Inoue, Takako, Nishino, Kazumi, Uchida, Junji, Kumagai, Toru, Okami, Jiro, Higasiyama, Masahiko, Kamoshida, Shingo
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492704/
https://ncbi.nlm.nih.gov/pubmed/28685068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mco.2017.1262
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