Experimental Prediction of the Evolution of Ceftazidime Resistance in the CTX-M-2 Extended-Spectrum Beta-Lactamase

We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC ≥ 32 μg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution...

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Bibliographic Details
Main Authors: Welsh, Kerry J., Barlow, Miriam, Tenover, Fred C., Biddle, James W., Rasheed, J. Kamile, Clark, Leigh Ann, McGowan, John E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549256/
https://ncbi.nlm.nih.gov/pubmed/15728940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1242-1244.2005
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