Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme

Novel N-3-alkylated 6-anilinouracils have been identified as potent and selective inhibitors of bacterial DNA polymerase IIIC, the enzyme essential for the replication of chromosomal DNA in gram-positive bacteria. A nonradioactive assay measuring the enzymatic activity of the DNA polymerase IIIC in...

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Autores principales: Kuhl, Alexander, Svenstrup, Niels, Ladel, Christoph, Otteneder, Michael, Binas, Annegret, Schiffer, Guido, Brands, Michael, Lampe, Thomas, Ziegelbauer, Karl, Rübsamen-Waigmann, Helga, Haebich, Dieter, Ehlert, Kerstin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC549236/
https://ncbi.nlm.nih.gov/pubmed/15728893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.987-995.2005
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