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Orally Active Antiviral Tripeptide Glycyl-Prolyl-Glycinamide Is Activated by CD26 (Dipeptidyl Peptidase IV) before Transport across the Intestinal Epithelium

The tripeptide amide glycyl-prolyl-glycinamide (GPG-amide) is a new antiretroviral drug candidate, but its absorption mechanism is unknown. In this investigation, the transport and metabolism of GPG-amide were studied in a model of the human intestinal epithelium, Caco-2 cell monolayers. The results...

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Bibliografiske detaljer
Main Authors: Hubatsch, Ina, Lazorova, Lucia, Vahlne, Anders, Artursson, Per
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC549227/
https://ncbi.nlm.nih.gov/pubmed/15728907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1087-1092.2005
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