Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice

BACKGROUND: Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possi...

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Autori principali: Gentschev, Ivaylo, Fensterle, Joachim, Schmidt, Andreas, Potapenko, Tamara, Troppmair, Jakob, Goebel, Werner, Rapp, Ulf R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC549196/
https://ncbi.nlm.nih.gov/pubmed/15703070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-15
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