Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1

IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule. Here, we sought to identify genetic factors contributing to levels of galactose-deficient IgA1 (Gd-IgA1) in white and Ch...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Gale, Daniel P., Molyneux, Karen, Wimbury, David, Higgins, Patricia, Levine, Adam P., Caplin, Ben, Ferlin, Anna, Yin, Peiran, Nelson, Christopher P., Stanescu, Horia, Samani, Nilesh J., Kleta, Robert, Yu, Xueqing, Barratt, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2017
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491291/
https://ncbi.nlm.nih.gov/pubmed/28209808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016091043
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