Targeting mTOR Signaling Can Prevent the Progression of FSGS

Mammalian target of rapamycin (mTOR) signaling is involved in a variety of kidney diseases. Clinical trials administering mTOR inhibitors to patients with FSGS, a prototypic podocyte disease, led to conflicting results, ranging from remission to deterioration of kidney function. Here, we combined co...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Zschiedrich, Stefan, Bork, Tillmann, Liang, Wei, Wanner, Nicola, Eulenbruch, Kristina, Munder, Stefan, Hartleben, Björn, Kretz, Oliver, Gerber, Simon, Simons, Matias, Viau, Amandine, Burtin, Martine, Wei, Changli, Reiser, Jochen, Herbach, Nadja, Rastaldi, Maria-Pia, Cohen, Clemens D, Tharaux, Pierre-Louis, Terzi, Fabiola, Walz, Gerd, Gödel, Markus, Huber, Tobias B
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2017
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491276/
https://ncbi.nlm.nih.gov/pubmed/28270414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016050519
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