Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin

A wide variety of drugs bind to human serum albumin (HSA) at its two principal sites, namely site I and site II. A number of reports indicate that drug binding to these two binding sites are not completely independent, and that interactions between ligands of these two discrete sites can play a role...

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Udgivet i:PLoS One
Main Authors: Yamasaki, Keishi, Hyodo, Saya, Taguchi, Kazuaki, Nishi, Koji, Yamaotsu, Noriyuki, Hirono, Shuichi, Chuang, Victor Tuan Giam, Seo, Hakaru, Maruyama, Toru, Otagiri, Masaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491222/
https://ncbi.nlm.nih.gov/pubmed/28662200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180404
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