A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion.
Although immunoglobulin light chains are usually secreted in association with heavy chains, free light chains can be secreted by lymphocytes. To identify the structural features of light chains that are essential for their secretion, we mutated a conserved sequence in the variable domain of a lambda...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1990
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2122454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.20.8135 |
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