Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

PURPOSE: Pupillary light reflex (PLR) is driven by outer retinal photoreceptors and by melanopsin-expressing intrinsically photosensitive retinal ganglion cells of the inner retina. To isolate the melanopic component, we studied patients with severe vision loss due to Leber congenital amaurosis (LCA...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Charng, Jason, Jacobson, Samuel G., Heon, Elise, Roman, Alejandro J., McGuigan, David B., Sheplock, Rebecca, Kosyk, Mychajlo S., Swider, Malgorzata, Cideciyan, Artur V.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490362/
https://ncbi.nlm.nih.gov/pubmed/28660274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21909
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