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Protein recognition of macrocycles: Binding of anti-HIV metallocyclams to lysozyme
The macrocyclic antiviral drug xylyl-bicyclam blocks entry of HIV into cells by targeting the CXCR4 coreceptor, a seven-helix transmembrane G-protein-coupled receptor. Its affinity for CXCR4 is enhanced by binding to Cu(2+), Ni(2+), or Zn(2+). Metallocyclams have a rich configurational chemistry and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548988/ https://ncbi.nlm.nih.gov/pubmed/15701702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407595102 |
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