Acute liver effects, disposition and metabolic fate of [(14)C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice

The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Pickup, Kathryn, Martin, Scott, Partridge, Elizabeth A., Jones, Huw B., Wills, Jonathan, Schulz-Utermoehl, Tim, McCarthy, Alan, Rodrigues, Alison, Page, Chris, Ratcliffe, Kerry, Sarda, Sunil, Wilson, Ian D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Toxicokinetics and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489613/
https://ncbi.nlm.nih.gov/pubmed/27896398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1894-5
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