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Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody

Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement regulatory proteins, including the soluble regulator c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Winkler, Mark T., Bushey, Ryan T., Gottlin, Elizabeth B., Campa, Michael J., Guadalupe, Eross S., Volkheimer, Alicia D., Weinberg, J. Brice, Patz, Edward F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489178/
https://ncbi.nlm.nih.gov/pubmed/28658265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179841
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