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Dynamic modeling of the tight junction pore pathway

Claudins define paracellular permeability to small molecules by forming ion-selective pores within the tight junction. We recently demonstrated that claudin-2 channels are gated and open and close on a submillisecond timescale. To determine if and how the ensemble behavior of this unique class of en...

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Bibliografiske detaljer
Udgivet i:Ann N Y Acad Sci
Main Authors: Weber, Christopher R., Turner, Jerrold R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488723/
https://ncbi.nlm.nih.gov/pubmed/28605031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13374
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