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Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
Tissues use feedback circuits in which cells send signals to each other to control their growth and survival. We show that such feedback circuits are inherently unstable to mutants that misread the signal level: Mutants have a growth advantage to take over the tissue, and cannot be eliminated by kno...
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| Udgivet i: | Mol Syst Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5488663/ https://ncbi.nlm.nih.gov/pubmed/28652282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20177599 |
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