Efficacy and Pharmacokinetics of the Combination of OP0595 and Cefepime in a Mouse Model of Pneumonia Caused by Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae

OP0595 (RG6080) is a novel diazabicyclooctane that inhibits class A and C serine beta-lactamases. Although the combination of OP0595 and cefepime (FEP) showed good in vitro activity against extended-spectrum-beta-lactamase (ESBL)-producing pathogens, the effect of the combination therapy against sev...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Kaku, Norihito, Kosai, Kosuke, Takeda, Kazuaki, Uno, Naoki, Morinaga, Yoshitomo, Hasegawa, Hiroo, Miyazaki, Taiga, Izumikawa, Koichi, Mukae, Hiroshi, Yanagihara, Katsunori
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487679/
https://ncbi.nlm.nih.gov/pubmed/28507106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00828-17
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