Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets

We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind serial passaging of the intestinal contents of a diarrheic piglet in Vero cell culture. Compared with the highly virulent U.S. PEDV strain PC21A, the tissue culture-adapted PC177 (TC-PC177) contains a 197-amino-a...

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Vydáno v:J Virol
Hlavní autoři: Hou, Yixuan, Lin, Chun-Ming, Yokoyama, Masaru, Yount, Boyd L., Marthaler, Douglas, Douglas, Arianna L., Ghimire, Shristi, Qin, Yibin, Baric, Ralph S., Saif, Linda J., Wang, Qiuhong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487580/
https://ncbi.nlm.nih.gov/pubmed/28490591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00227-17
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