Pathogenic Events in a Nonhuman Primate Model of Oral Poliovirus Infection Leading to Paralytic Poliomyelitis

Despite a great deal of prior research, the early pathogenic events in natural oral poliovirus infection remain poorly defined. To establish a model for study, we infected 39 macaques by feeding them single high doses of the virulent Mahoney strain of wild type 1 poliovirus. Doses ranging from 10(7)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Shen, Ling, Chen, Crystal Y., Huang, Dan, Wang, Richard, Zhang, Meihong, Qian, Lixia, Zhu, Yanfen, Zhang, Alvin Zhuoran, Yang, Enzhuo, Qaqish, Arwa, Chumakov, Konstantin, Kouiavskaia, Diana, Vignuzzi, Marco, Nathanson, Neal, Macadam, Andrew J., Andino, Raul, Kew, Olen, Xu, Junfa, Chen, Zheng W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487571/
https://ncbi.nlm.nih.gov/pubmed/28356537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02310-16
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