2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway

2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneall...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Zhemin, Qiu, Zewen, Gao, Chenxue, Sun, Yijie, Dong, Wei, Zhang, Yan, Chen, Ruolin, Qi, Yuan, Li, Shuangyue, Guo, Yanjie, Piao, Yongjun, Li, Sheng, Piao, Fengyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487034/
https://ncbi.nlm.nih.gov/pubmed/28654704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179388
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados