Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells. Here...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Eckert, Franziska, Jelas, Ivan, Oehme, Moritz, Huber, Stephan M., Sonntag, Katja, Welker, Christian, Gillies, Stephen D., Strittmatter, Wolfgang, Zips, Daniel, Handgretinger, Rupert, Schilbach, Karin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486191/
https://ncbi.nlm.nih.gov/pubmed/28680762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1323161
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