The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival

Microenvironmental regulation in lymphoid tissues is essential for the development of chronic lymphocytic leukemia. We identified cellular and molecular factors provided by the splenic marginal zone (MZ), which alter the migratory and adhesive behavior of leukemic cells. We used the Cxcr5(−/−)Eµ-Tcl...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Stache, Vanessa, Verlaat, Lydia, Gätjen, Marcel, Heinig, Kristina, Westermann, Jörg, Rehm, Armin, Höpken, Uta E.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486190/
https://ncbi.nlm.nih.gov/pubmed/28680761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1323155
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