Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition

Expression of human epidermal growth factor family member 3 (HER3), a critical heterodimerization partner with EGFR and HER2, promotes more aggressive biology in breast and other epithelial malignancies. As such, inhibiting HER3 could have broad applicability to the treatment of EGFR- and HER2-drive...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Osada, Takuya, Morse, Michael A., Hobeika, Amy, Diniz, Marcio A., Gwin, William R., Hartman, Zachary, Wei, Junping, Guo, Hongtao, Yang, Xiao-Yi, Liu, Cong-Xiao, Kaneko, Kensuke, Broadwater, Gloria, Lyerly, H. Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486174/
https://ncbi.nlm.nih.gov/pubmed/28680745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1315495
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