DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age

We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of hero...

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Veröffentlicht in:Genes (Basel)
Hauptverfasser: Kozlenkov, Alexey, Jaffe, Andrew E., Timashpolsky, Alisa, Apontes, Pasha, Rudchenko, Sergei, Barbu, Mihaela, Byne, William, Hurd, Yasmin L., Horvath, Steve, Dracheva, Stella
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485516/
https://ncbi.nlm.nih.gov/pubmed/28556790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes8060152
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