Tanshinone IIA Inhibits Glutamate-Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH-SY5Y Human Neuroblastoma Cells

Glutamate excitotoxicity is associated with many neurological diseases, including cerebral ischemia and neurodegenerative diseases. Tanshinone IIA, a diterpenoid naphthoquinone from Salvia miltiorrhiza, has been shown to suppress presynaptic glutamate release, but its protective mechanism against gl...

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Publicado en:Oxid Med Cell Longev
Autores principales: Li, Haifeng, Han, Wenjing, Wang, Hongyu, Ding, Fei, Xiao, Lingyun, Shi, Ruona, Ai, Liping, Huang, Zebo
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485345/
https://ncbi.nlm.nih.gov/pubmed/28690763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4517486
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