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Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis

Secukinumab is a human monoclonal antibody with demonstrated efficacy for moderate to severe psoriasis; it binds to and neutralizes interleukin (IL)‐17A. The pharmacokinetic (PK) parameters of secukinumab were best described by a 2‐compartment model. Only weight was included in the final model, as o...

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Vydáno v:J Clin Pharmacol
Hlavní autoři: Bruin, Gerard, Loesche, Christian, Nyirady, Judit, Sander, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485066/
https://ncbi.nlm.nih.gov/pubmed/28273356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.876
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