The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

The conserved protein kinase Sch9 is a central player in the nutrient-induced signaling network in yeast, although only few of its direct substrates are known. We now provide evidence that Sch9 controls the vacuolar proton pump (V-ATPase) to maintain cellular pH homeostasis and ageing. A synthetic s...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Wilms, Tobias, Swinnen, Erwin, Eskes, Elja, Dolz-Edo, Laura, Uwineza, Alice, Van Essche, Ruben, Rosseels, Joëlle, Zabrocki, Piotr, Cameroni, Elisabetta, Franssens, Vanessa, De Virgilio, Claudio, Smits, Gertien J., Winderickx, Joris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484544/
https://ncbi.nlm.nih.gov/pubmed/28604780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006835
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