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Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

PURPOSE: Agomelatine is a novel antidepressant drug suffering from an extensive first-pass metabolism leading to a diminished absolute bioavailability. The aim of the study is: first to enhance its absolute bioavailability, and second to increase its brain delivery. METHODS: To achieve these aims, t...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Fatouh, Ahmed M, Elshafeey, Ahmed H, Abdelbary, Ahmed
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484509/
https://ncbi.nlm.nih.gov/pubmed/28684900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S102500
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