Synthetic Double-Stranded RNA Poly(I:C) Combined with Mucosal Vaccine Protects against Influenza Virus Infection

The mucosal adjuvant effect of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid [poly(I:C)] against influenza virus was examined under intranasal coadministration with inactivated hemagglutinin (HA) vaccine in BALB/c mice and was shown to have a protective effect against both na...

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Bibliographic Details
Main Authors: Ichinohe, Takeshi, Watanabe, Izumi, Ito, Satoshi, Fujii, Hideki, Moriyama, Masami, Tamura, Shin-ichi, Takahashi, Hidehiro, Sawa, Hirofumi, Chiba, Joe, Kurata, Takeshi, Sata, Tetsutaro, Hasegawa, Hideki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC548446/
https://ncbi.nlm.nih.gov/pubmed/15709010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.2910-2919.2005
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