Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to 14-3-3 Proteins and Facilitates Complex Formation with Cdc25C: Implications for Cell Cycle Arrest

Vpr and selected mutants were used in a Saccharomyces cerevisiae two-hybrid screen to identify cellular interactors. We found Vpr interacted with 14-3-3 proteins, a family regulating a multitude of proteins in the cell. Vpr mutant R80A, which is inactive in cell cycle arrest, did not interact with 1...

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Main Authors: Kino, Tomoshige, Gragerov, Alexander, Valentin, Antonio, Tsopanomihalou, Maria, Ilyina-Gragerova, Galina, Erwin-Cohen, Rebecca, Chrousos, George P., Pavlakis, George N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548435/
https://ncbi.nlm.nih.gov/pubmed/15708996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.2780-2787.2005
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