Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to 14-3-3 Proteins and Facilitates Complex Formation with Cdc25C: Implications for Cell Cycle Arrest

Vpr and selected mutants were used in a Saccharomyces cerevisiae two-hybrid screen to identify cellular interactors. We found Vpr interacted with 14-3-3 proteins, a family regulating a multitude of proteins in the cell. Vpr mutant R80A, which is inactive in cell cycle arrest, did not interact with 1...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Kino, Tomoshige, Gragerov, Alexander, Valentin, Antonio, Tsopanomihalou, Maria, Ilyina-Gragerova, Galina, Erwin-Cohen, Rebecca, Chrousos, George P., Pavlakis, George N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2005
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548435/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15708996/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.5.2780-2787.2005
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