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Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness

The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co-agonist-binding site. In most brain regions, the NMDAR co-agonist is the astrocyte-derived gliotransmitter D-serine. We found that D-serine levels oscilla...

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Bibliografiske detaljer
Udgivet i:Neuron
Main Authors: Papouin, Thomas, Dunphy, Jaclyn, Tolman, Michaela, Dineley, Kelly T., Haydon, Philip G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484087/
https://ncbi.nlm.nih.gov/pubmed/28479102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.04.021
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