Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/Macrophages

Brucella spp. infection results in compromised Type1 (Th1) cellular immune response. Several reports have described an immunomodulatory function for Brucella major outer membrane protein Omp25. However, the mechanism by which Omp25 modulates macrophage dysfunction has not been defined. Herein, we re...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cui, Beibei, Liu, Wenli, Wang, Xiaoya, Chen, Yu, Du, Qian, Zhao, Xiaomin, Zhang, Hai, Liu, Shan-Lu, Tong, Dewen, Huang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483987/
https://ncbi.nlm.nih.gov/pubmed/28694807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00708
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