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The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles

Rheumatoid arthritis is a chronic inflammatory disease characterized by destruction of cartilage and bone that is mediated by synovial fibroblasts. To determine the mechanisms by which these cells are activated to produce matrix metalloproteinases (MMPs), the effects of microparticles were investiga...

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Bibliographische Detailangaben
Hauptverfasser: Distler, Jörg H. W., Jüngel, Astrid, Huber, Lars C., Seemayer, Christian A., Reich, Charles F., Gay, Renate E., Michel, Beat A., Fontana, Adriano, Gay, Steffen, Pisetsky, David S., Distler, Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC548330/
https://ncbi.nlm.nih.gov/pubmed/15701693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409781102
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