The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Malonyl-CoA is a central metabolite in mammalian fatty acid biochemistry generated and utilized in the cytoplasm; however, little is known about noncanonical organelle-specific malonyl-CoA metabolism. Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3, that produces malon...

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Pubblicato in:Cell Chem Biol
Autori principali: Bowman, Caitlyn E., Rodriguez, Susana, Selen Alpergin, Ebru S., Acoba, Michelle G., Zhao, Liang, Hartung, Thomas, Claypool, Steven M., Watkins, Paul A., Wolfgang, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482780/
https://ncbi.nlm.nih.gov/pubmed/28479296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.04.009
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