Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition

BACKGROUND: ABCB1 expression is uncommon in ovarian cancers in the clinical setting so we investigated non-MDR mechanisms of resistance to taxanes. METHODS: We established eight taxane-resistant variants from the human ovarian carcinoma cell lines A2780/1A9, ES-2, MES-OV and OVCAR-3 by selection wit...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Duran, George E, Wang, Yan C, Moisan, François, Francisco, E Brian, Sikic, Branimir I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482726/
https://ncbi.nlm.nih.gov/pubmed/28399108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.102
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