Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to X-rays, carbon ion irradiation relies on better ballistic properties, higher relative biological effectiveness and the absen...

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Vydáno v:Br J Cancer
Hlavní autoři: Wozny, Anne-Sophie, Lauret, Alexandra, Battiston-Montagne, Priscillia, Guy, Jean-Baptiste, Beuve, Michael, Cunha, Micaela, Saintigny, Yannick, Blond, Emilie, Magne, Nicolas, Lalle, Philippe, Ardail, Dominique, Alphonse, Gersende, Rodriguez-Lafrasse, Claire
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482725/
https://ncbi.nlm.nih.gov/pubmed/28407653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.100
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