Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship

Apolipoprotein (apo) E3 and apoAI are exchangeable apolipoproteins that play a dominant role in regulating plasma lipoprotein metabolism. ApoE3 (299 residues) is composed of an N-terminal (NT) domain bearing a 4-helix bundle and a C-terminal (CT) domain bearing a series of amphipathic α-helices. Apo...

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Vydáno v:PLoS One
Hlavní autoři: Lek, Mark T., Cruz, Siobanth, Ibe, Nnejiuwa U., Beck, Wendy H. J., Bielicki, John K., Weers, Paul M. M., Narayanaswami, Vasanthy
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482431/
https://ncbi.nlm.nih.gov/pubmed/28644829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178346
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